MEMS, Electronic and Optoelectronic Biosensors

Introduction

The objective of this research is to develop biosensors capable of detecting the presence of biological molecules (DNA and proteins) and cells. Several detection principles are explored: (i) electromechanical, using thin-film MEMS; (ii) optoelectronic, using thin-film amorphous silicon light sensors; (iii) electronic, using ion-sensitive thin-film amorphous silicon transistors. A recent development has been the incorporation of these devices with PDMS-based lab-on-a-chip microfluidic devices.

For more information about this topic, contact João Pedro Conde or Virginia Chu. 

Main Results

• Thin-film silicon MEMS microresonators for DNA and protein detection

• Integrated thin-film silicon chemiluminescence sensors for protein detection

• Integrated thin-film silicon photoluminescence sensors for DNA and protein detection

• Thin-film silicon ISFETs for DNA and protein detection

• Microfluidic devices for biosensors and cell-chips

Projects and Collaborations 2004 - present

• This work is done in collaboration with the Biological Engineering Research Group (BERG), of the Institute for Biotechnology and Bioengineering (IBB) (Miguel Prazeres, Gabriel Monteiro).

• “Microelectromechanical resonators: high sensitivity DNA detectors (BioMEMS)” (POCTI/CTM/37719/01). Partners: INESC-MN, BERG

• “Electronic detection of biomolecules for microarray applications (BioDetect)” (POCTI/CTM/58636/2004). Partners: INESC-MN, BERG.

• "A Lab-on-a-chip-based 2D fluorescence detection system for organism/cell condition analysis (Micro-2D-FS)" (PTDC/CTM/104387/2008). Partners: INESC-MN, BERG

• OTASENSE (Biosensors for Ochratoxin A detection):  EU FP7 project, Dec. 2009 – Nov. 2011

• Nanomed (Lab-on-chip technologies): PortugalNano (FCT), Aug. 2009 – July 2011

Industrial Collaborations

“Development of lab-on-a-chip biosensors”, Partner: Lumisense

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