Biomedical and Nano-Bio Applications

Introduction

Research in this area started at the end of 2005. Work is progressing along three projects. 1-Hybrid sensors for fT field detection (ACMEMS+magnetic flux guides+high sensitivity MR sensors, within the BIOMAGSENSE FP6 project). 2-Development of an integrated solid state switch driven by a molecular motor (MR or Hall effect nanosensor within a microfluidic channel, detecting the vertical position of a magnetric nanobead at the end of a stretched um long DNA chain, within the BioMolSwitch FP6 project). 3-Developmenbt of a MR sensor based set up (microelectrodes + sensing sites) to measure synaptic currents (test vs patch clamp results).

 For more information about this topic, contact Paulo Freitas.

Main Results

• Hybrid sensors for fT field detection: biomedical imaging

• DNA translocation monitoring  using magnetic tweezers and MR sensors

• Microelectrodes for neuroelectronics and for synaptic current monitoring

Projects and Collaborations 2004 - present

• “BIOMAGSENSE”, FP6_NMP4_CT_2005_017210 , CEA Orsay (coordinator), INESC MN, Trinity College IR, Elekta Neuromag Finland, CEDRAT FR.

• “BioNanoSwitch”, FP6_2005_NEST_043288, U.Portsmouth (coordinator), INESC MN, CNRS-ENS-Paris, TU Delft, Inst. Of Microbiology of the Academy of Sciences,Prague, Swiss Federal Lab for Materials Testing and Research-Switzerland.

• INESC-MN-IBMC/UP (planar microelectrodes for neuroelectronics, started March 2006)

• INESC MN-IMM/FMUL (MR sensor chip for synaptic current monitoring , started Dec 2006)

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